U.S. street drug deaths fell roughly 14% in 2025 to 69,973 fatalities, marking the lowest 12-month toll since at least 2019, according to CDC data. However, some Western states including Arizona, New Mexico, and North Dakota saw sharp increases in overdose deaths, with experts citing more potent fentanyl, methamphetamines, and gaps in treatment access.
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U.S. street drug deaths fell roughly 14% in 2025 to 69,973 fatalities, marking the lowest 12-month toll since at least 2019, according to CDC data. However, some Western states including Arizona, New Mexico, and North Dakota saw sharp increases in overdose deaths, with experts citing more potent fentanyl, methamphetamines, and gaps in treatment access.